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Literature summary extracted from

  • Alam, M.M.; Mohammad, A.A.; Shuaib, U.; Wang, C.; Ghani, U.; Schwindt, B.; Todd, K.G.; Shuaib, A.
    Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis (2009), J. Cereb. Blood Flow Metab., 29, 157-165.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.56 homocysteine induces the enzyme activation 2.5fold and 4fold in endothelial progenitor cells at 0.1 mM and 0.2 mM, respectively. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, and inhibitor N-carbobenzyloxy-VAD-fluoromethyl ketone highly reduces the activating effect, overview Homo sapiens
3.4.22.61 homocysteine induces the enzyme activation 3.5fold in endothelial progenitor cells at 0.2 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.56 N-carbobenzyloxy-VAD-fluoromethyl ketone a general caspase inhibitor Homo sapiens
3.4.22.61 N-carbobenzyloxy-IETD-fluoromethyl ketone a caspase-8-specific inhibitor Homo sapiens
3.4.22.61 N-carbobenzyloxy-VAD-fluoromethyl ketone a general caspase inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.56 additional information Homo sapiens homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, overview ?
-
?
3.4.22.61 additional information Homo sapiens homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.56 Homo sapiens
-
-
-
3.4.22.61 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.56 endothelial progenitor cell
-
Homo sapiens
-
3.4.22.61 endothelial progenitor cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.56 additional information
-
-
Homo sapiens
3.4.22.61 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.56 additional information homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, overview Homo sapiens ?
-
?
3.4.22.61 additional information homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation, overview Homo sapiens ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.56 37
-
assay at Homo sapiens
3.4.22.61 37
-
assay at Homo sapiens