EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.56 | homocysteine | induces the enzyme activation 2.5fold and 4fold in endothelial progenitor cells at 0.1 mM and 0.2 mM, respectively. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, and inhibitor N-carbobenzyloxy-VAD-fluoromethyl ketone highly reduces the activating effect, overview | Homo sapiens | |
3.4.22.61 | homocysteine | induces the enzyme activation 3.5fold in endothelial progenitor cells at 0.2 mM | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.56 | N-carbobenzyloxy-VAD-fluoromethyl ketone | a general caspase inhibitor | Homo sapiens | |
3.4.22.61 | N-carbobenzyloxy-IETD-fluoromethyl ketone | a caspase-8-specific inhibitor | Homo sapiens | |
3.4.22.61 | N-carbobenzyloxy-VAD-fluoromethyl ketone | a general caspase inhibitor | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.56 | additional information | Homo sapiens | homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, overview | ? | - |
? | |
3.4.22.61 | additional information | Homo sapiens | homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.56 | Homo sapiens | - |
- |
- |
3.4.22.61 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.56 | endothelial progenitor cell | - |
Homo sapiens | - |
3.4.22.61 | endothelial progenitor cell | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.22.56 | additional information | - |
- |
Homo sapiens |
3.4.22.61 | additional information | - |
- |
Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.56 | additional information | homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation. Vitamin B6, and B9 significantly impair homocysteine-mediated EPC caspase-3 activation in vitro, overview | Homo sapiens | ? | - |
? | |
3.4.22.61 | additional information | homocysteine-mediated EPC toxicity is due to apoptosis involving caspase-8, cytochrome c release, and caspase-3 activation, overview | Homo sapiens | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.22.56 | 37 | - |
assay at | Homo sapiens |
3.4.22.61 | 37 | - |
assay at | Homo sapiens |