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Literature summary extracted from

  • Mirandola, P.; Gobbi, G.; Sponzilli, I.; Malinverno, C.; Cavazzoni, A.; Alfieri, R.; Petronini, P.G.; Vitale, M.
    TRAIL-induced apoptosis of FHIT-negative lung cancer cells is inhibited by FHIT re-expression (2009), J. Cell. Physiol., 220, 493-498.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.29 constitutive expression of FHIT in Calu-1 cells, endogenously lacking FHIT protein, FHIT re-expression does not affect cell survival, but a Calu-1 cell clone in which the expression of FHIT is under the control of a CMV promoter, is more resistant to TRAIL-induced, i.e. tumor necrosis factor-related apoptosis inducing ligand-induced, apoptosis than the mock transfected Calu-1 clones Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.29 additional information FHIT-specific small interference RNA transfection of SV40-immortalized normal bronchial BEAS cells that show levels of FHIT protein comparable to those of normal bronchial cells, results in a significant increase of TRAIL-induced apoptosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.29 suramin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.29 additional information Homo sapiens diadenosine oligophosphates, ApnA, have emerged as putative extra- and intracellular signaling molecules implicated in the maintenance and regulation of vital cellular functions and are now considered as a new class of signal transducers. FHIT induction protects from tumor necrosis factor-related apoptosis inducing ligand-induced cell death downstream TRAIL-receptors and likely requires its dinucleoside-triphosphate hydrolase activity, overview ?
-
 ?
3.6.1.29 P1,P3-bis(5'-adenosyl) triphosphate + H2O Homo sapiens FHIT protein has been shown to function as a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, forming ADP and AMP from the Ap3A substrate. Tumor suppression by FHIT occurs in lung, gastric, and renal carcinoma-derived cell lines, with Ap3A hydrolysis by FHIT being not necessary for the tumor suppressive activity ADP + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.29 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.1.29 bronchial epithelial cell line a human SV40-immortalized normal bronchial epithelial cell line Homo sapiens
-
3.6.1.29 gastric cancer cell
-
 Homo sapiens
-
3.6.1.29 kidney cancer cell
-
 Homo sapiens
-
3.6.1.29 lung cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.29 additional information diadenosine oligophosphates, ApnA, have emerged as putative extra- and intracellular signaling molecules implicated in the maintenance and regulation of vital cellular functions and are now considered as a new class of signal transducers. FHIT induction protects from tumor necrosis factor-related apoptosis inducing ligand-induced cell death downstream TRAIL-receptors and likely requires its dinucleoside-triphosphate hydrolase activity, overview Homo sapiens ?
-
 ?
3.6.1.29 P1,P3-bis(5'-adenosyl) triphosphate + H2O
-
 Homo sapiens ADP + AMP
-
 ?
3.6.1.29 P1,P3-bis(5'-adenosyl) triphosphate + H2O FHIT protein has been shown to function as a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, forming ADP and AMP from the Ap3A substrate. Tumor suppression by FHIT occurs in lung, gastric, and renal carcinoma-derived cell lines, with Ap3A hydrolysis by FHIT being not necessary for the tumor suppressive activity Homo sapiens ADP + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.29 Ap3A hydrolase
-
 Homo sapiens
3.6.1.29 dinucleoside 5',5'''-P1,P3-triphosphate hydrolase
-
 Homo sapiens
3.6.1.29 Fhit
-
 Homo sapiens
3.6.1.29 fragile histidine triad
-
 Homo sapiens