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Literature summary extracted from

  • Ulu, A.; Davis, B.B.; Tsai, H.J.; Kim, I.H.; Morisseau, C.; Inceoglu, B.; Fiehn, O.; Hammock, B.D.; Weiss, R.H.
    Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model (2008), J. Cardiovasc. Pharmacol., 52, 314-323.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.3.2.10 medicine sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease Mus musculus
3.3.2.10 medicine sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.10
-
 Mus musculus
3.3.2.10
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea highly potent and selective sEH inhibitor Homo sapiens
3.3.2.10 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea highly potent and selective sEH inhibitor Mus musculus
3.3.2.10 12-(3-adamantan-1-yl-ureido)dodecanoic acid potent transition state inhibitor of sEH Homo sapiens
3.3.2.10 12-(3-adamantan-1-yl-ureido)dodecanoic acid potent transition state inhibitor of sEH Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens
-
-
-
3.3.2.10 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.10
-
 Mus musculus
3.3.2.10
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O i.e. 8,9-EET Mus musculus (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid i.e. 8,9-DHET ?
3.3.2.10 (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O i.e. 14,15-EET Mus musculus (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid i.e. 14,15-DHET ?
3.3.2.10 (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O i.e. 11,12-EET Mus musculus (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid i.e. 11,12-DHET ?
3.3.2.10 11,12-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens 11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens 14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 5,6-epoxyeicosatrienoic acid + H2O
-
 Mus musculus 5,6-hydroxyeicosatrienoic acid
-
 ?
3.3.2.10 5,6-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens 5,6-hydroxyeicosatrienoic acid
-
 ?
3.3.2.10 8,9-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens 8,9-hydroxyeicosatrienoic acid
-
 ?
3.3.2.10 alpha-cyanocarbonate epoxide + H2O
-
 Mus musculus ?
-
 ?
3.3.2.10 alpha-cyanocarbonate epoxide + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 SEH
-
 Mus musculus
3.3.2.10 SEH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.10 0.000003
-
 purified recombinant enzyme Homo sapiens 12-(3-adamantan-1-yl-ureido)dodecanoic acid
3.3.2.10 0.000003
-
 purified recombinant enzyme Mus musculus 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea
3.3.2.10 0.00001
-
 purified recombinant enzyme Mus musculus 12-(3-adamantan-1-yl-ureido)dodecanoic acid
3.3.2.10 0.000014
-
 purified recombinant enzyme Homo sapiens 1-adamantan-3-(5-(2-(2-ethylethoxy)ethoxy)pentyl)urea