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Literature summary extracted from

  • Kostera, J.; Youngblut, M.D.; Slosarczyk, J.M.; Pacheco, A.A.
    Kinetic and product distribution analysis of NO. reductase activity in Nitrosomonas europaea hydroxylamine oxidoreductase (2008), J. Biol. Inorg. Chem., 13, 1073-1083.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.7.2.8 additional information
-
 additional information kinetics, both reaction steps show first-order dependence on nitric oxide Nitrosomonas europaea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.7.2.8 hydroxylamine + NH3 + cytochrome c-554 Nitrosomonas europaea the ammonia-oxidizing bacterium Nitrosomonas europaea normally catalyzes the four-electron oxidation of hydroxylamine to nitrite, which is the second step in ammonia-dependent respiration. In the presence of methyl viologen monocation radical, HAO can catalyze the reduction of nitric oxide to ammonia, reaction of by cytochrome c nitrite reductase , EC 1.7.2.2, overview NO2 + H2O + reduced cytochrome c-554
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.7.2.8 Nitrosomonas europaea
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.7.2.8 hydroxylamine + NH3 + acceptor = N2 + H2O + reduced acceptor catalytic mechanism, overview Nitrosomonas europaea
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.2.8 hydroxylamine + NH3 + cytochrome c-554
-
 Nitrosomonas europaea NO2 + H2O + reduced cytochrome c-554
-
 ?
1.7.2.8 hydroxylamine + NH3 + cytochrome c-554 the ammonia-oxidizing bacterium Nitrosomonas europaea normally catalyzes the four-electron oxidation of hydroxylamine to nitrite, which is the second step in ammonia-dependent respiration. In the presence of methyl viologen monocation radical, HAO can catalyze the reduction of nitric oxide to ammonia, reaction of by cytochrome c nitrite reductase , EC 1.7.2.2, overview Nitrosomonas europaea NO2 + H2O + reduced cytochrome c-554
-
 ?
1.7.2.8 additional information the enzyme catalyzes the four-electron oxidation of NH2OH to nitrite under aerobic conditions, HAO reacts with NO radical and NH2OH under reducing conditions Nitrosomonas europaea ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.7.2.8 More arrangement of the eight hemes within one subunit of hydroxylamine oxidoreductase, structure, overview Nitrosomonas europaea

Synonyms

EC Number Synonyms Comment Organism
1.7.2.8 HAO
-
 Nitrosomonas europaea
1.7.2.8 hydroxylamine oxidoreductase
-
 Nitrosomonas europaea

Cofactor

EC Number Cofactor Comment Organism Structure
1.7.2.8 cytochrome c554 a soluble 26.1-kDa tetraheme protein that is quite abundant in the periplasm of Nitrosomas europaea and is the acceptor of the electrons from HAO in vivo Nitrosomonas europaea
1.7.2.8 cytochrome P460 heme-containing cofactor, overview Nitrosomonas europaea
1.7.2.8 heme several, structure and organization, overview Nitrosomonas europaea