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Literature summary extracted from

  • Noh, Y.H.; Baek, J.Y.; Jeong, W.; Rhee, S.G.; Chang, T.S.
    Sulfiredoxin Translocation into Mitochondria Plays a Crucial Role in Reducing Hyperoxidized Peroxiredoxin III (2009), J. Biol. Chem., 284, 8470-8477.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.98.2 the vectors pcDNA3 and pFLAG-CMV2 are used, a leader sequence is cloned into the N-terminus coding region of Srx Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.8.98.2 C99S catalytic cysteine mutant Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.98.2 cytosol cytosolic Srx is translocated into the mitochondria under oxidative conditions Homo sapiens 5829
-
1.8.98.2 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH Homo sapiens
-
 peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.98.2 A-549 cell
-
 Homo sapiens
-
1.8.98.2 HEK-293 cell
-
 Homo sapiens
-
1.8.98.2 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH
-
 Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.2 Srx
-
 Homo sapiens
1.8.98.2 sulfiredoxin
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.98.2 ATP
-
 Homo sapiens