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Literature summary extracted from

  • Zhao, X.; Yu, S.; Ranguelova, K.; Suarez, J.; Metlitsky, L.; Schelvis, J.P.; Magliozzo, R.S.
    Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant (2009), J. Biol. Chem., 284, 7030-7037.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.21 expressed in Escherichia coli cells Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.21 M255A the mutant exhibits severely reduced catalase activity compared to the wild type enzyme Mycobacterium tuberculosis
1.11.1.21 W107F the mutant exhibits severely reduced catalase activity yet normal peroxidase activity and contains more abundant 6-coordinate heme in high spin and low spin forms compared to the wild type enzyme Mycobacterium tuberculosis
1.11.1.21 Y229F the mutant exhibits severely reduced catalase activity compared to the wild type enzyme Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis P9WIE5
-
-
1.11.1.21 Mycobacterium tuberculosis H37Rv P9WIE5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.21
-
 Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis O2 + H2O
-
 ?
1.11.1.21 H2O2
-
 Mycobacterium tuberculosis H37Rv O2 + H2O
-
 ?
1.11.1.21 o-dianisidine + H2O2
-
 Mycobacterium tuberculosis ?
-
 ?
1.11.1.21 o-dianisidine + H2O2
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?
1.11.1.21 tert-butyl peroxide + H2O2
-
 Mycobacterium tuberculosis ?
-
 ?
1.11.1.21 tert-butyl peroxide + H2O2
-
 Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.21 catalase-peroxidase
-
 Mycobacterium tuberculosis
1.11.1.21 KatG
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.21 heme
-
 Mycobacterium tuberculosis