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Literature summary extracted from

  • Maghzal, G.J.; Leck, M.C.; Collinson, E.; Li, C.; Stocker, R.
    Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase (2009), J. Biol. Chem., 284, 29251-29259.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.24 into the pGEM-T easy vector, subcloned into the vectors pcDNA3 and pESC-LEU Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.24 siRNA
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 bilirubin + NADP+ Homo sapiens
-
 biliverdin + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 HeLa cell
-
 Homo sapiens
-
1.3.1.24 Hep-G2 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.24 0.0001
-
 HeLa cells transfected with BVR-targeted RNAi Homo sapiens
1.3.1.24 0.00035
-
 BVR activity in HeLa cells, control Homo sapiens
1.3.1.24 0.00075
-
 HeLa cells transfected with pcDNA3-BVR, overexpression of BVR Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 bilirubin + NADP+
-
 Homo sapiens biliverdin + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 biliverdin reductase
-
 Homo sapiens
1.3.1.24 BVR
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.3.1.24 37
-
 activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.24 7.3
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NADPH
-
 Homo sapiens