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Literature summary extracted from
- Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin (2009), J. Biol. Chem., 284, 23364-23374.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.98.2 | for expression in Escherichia coli BL21DE3 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.8.98.2 | H100N | Srx mutant | Homo sapiens |
| 1.8.98.2 | R101M | Srx mutant | Homo sapiens |
| 1.8.98.2 | Y92R | Srx mutant | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.98.2 | siRNA | - |
Homo sapiens |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.98.2 | Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.98.2 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH | Homo sapiens | - |
peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.98.2 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.98.2 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.98.2 | A-549 cell | - |
Homo sapiens | - |
| 1.8.98.2 | HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.98.2 | additional information | catalyzes the deglutathionylation of actin | Homo sapiens | ? | - |
? | |
| 1.8.98.2 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + R-SH | - |
Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.98.2 | Srx | - |
Homo sapiens |
| 1.8.98.2 | sulfiredoxin | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.98.2 | ATP | - |
Homo sapiens | |
| 1.8.98.2 | glutathione | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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