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Literature summary extracted from

  • Guyot, N.; Butler, M.W.; McNally, P.; Weldon, S.; Greene, C.M.; Levine, R.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
    Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis (2008), J. Biol. Chem., 283, 32377-32385.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.37 alpha-1-antichymotrypsin
-
 Homo sapiens
3.4.21.37 alpha-1-antitrypsin neutrophil elastase is inactivated by 0.005 mg of alpha-1-antitrypsin for 30 min Homo sapiens
3.4.21.37 elafin substrate inhibitor of neutrophil elastase, the purified fragments of the cleaved inhibitor elafin, Lys6-Gln57 and Ser10-Gln57, are also still active for inhibiting neutrophil elastase Homo sapiens
3.4.21.37 additional information neither leupeptin, E-64, pepstatin A, benzamidine, soybean trypsin inhibitor, Nalpha-tosyl-L-lysine chloromethyl ketone, N-p-tosyl-L-phenylalanine chloromethyl ketone, EDTA, GM6001, nor phosphoramidon have any inhibitory effect Homo sapiens
3.4.21.37 N-(methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
-
 Homo sapiens
3.4.21.37 pefabloc
-
 Homo sapiens
3.4.21.37 secretory leukoprotease inhibitor
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.37 elafin + H2O Homo sapiens elafin is cleaved by its cognate enzyme neutrophil elastase, neutrophil elastase-mediated cleavage of elafin abolishes the capacity of the inhibitor to cross-link to fibronectin by transglutamination, neutrophil elastase-mediated cleavages of elafin at Val5-Lys-6 and Val9-Ser10 peptide bonds only occur with 2x excess of neutrophil elastase, a partial cleavage of the inhibitor is identified at the scissile peptide bond Ala24-Met25 ?
-
 ?
3.4.21.37 Fibronectin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.37 sputum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.37 elafin + H2O elafin is cleaved by its cognate enzyme neutrophil elastase, neutrophil elastase-mediated cleavage of elafin abolishes the capacity of the inhibitor to cross-link to fibronectin by transglutamination, neutrophil elastase-mediated cleavages of elafin at Val5-Lys-6 and Val9-Ser10 peptide bonds only occur with 2x excess of neutrophil elastase, a partial cleavage of the inhibitor is identified at the scissile peptide bond Ala24-Met25 Homo sapiens ?
-
 ?
3.4.21.37 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.37 N-methoxysuccinyl-Ala-Ala-Pro-Val-4-nitroanilide + H2O
-
 Homo sapiens N-methoxysuccinyl-Ala-Ala-Pro-Val + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.37 neutrophil elastase
-
 Homo sapiens