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Literature summary extracted from

  • Szabo, R.; Hobson, J.P.; List, K.; Molinolo, A.; Lin, C.Y.; Bugge, T.H.
    Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity (2008), J. Biol. Chem., 283, 29495-29504.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.109 hepatocyte growth factor activator inhibitor-1 HAI-1 Homo sapiens
3.4.21.109 hepatocyte growth factor activator inhibitor-1 HAI-1 Mus musculus
3.4.21.109 hepatocyte growth factor activator inhibitor-2 HAI-2 Homo sapiens
3.4.21.109 hepatocyte growth factor activator inhibitor-2 HAI-2 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.109 membrane
-
Mus musculus 16020
-
3.4.21.109 membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.109 pro-urokinase-type plasminogen activator + H2O Mus musculus
-
?
-
?
3.4.21.109 pro-urokinase-type plasminogen activator + H2O Homo sapiens
-
?
-
?
3.4.21.109 prostatin + H2O Mus musculus
-
?
-
?
3.4.21.109 prostatin + H2O Homo sapiens
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.109 Homo sapiens
-
-
-
3.4.21.109 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.109 antral follicle ovary Mus musculus
-
3.4.21.109 bile duct epithelium liver Mus musculus
-
3.4.21.109 cerebral cortex skin Mus musculus
-
3.4.21.109 collecting duct kidney Mus musculus
-
3.4.21.109 crypt jejunum, ileum, colon Mus musculus
-
3.4.21.109 epithelial cell
-
Homo sapiens
-
3.4.21.109 epithelium esophagus and forestomach, suprabasal layer, trachea, bronchi, bronchioles, bladder Mus musculus
-
3.4.21.109 goblet cell colon Mus musculus
-
3.4.21.109 granulosa cell ovary Mus musculus
-
3.4.21.109 hair follicle inner root sheath skin Mus musculus
-
3.4.21.109 lip epithelium oral cavity Mus musculus
-
3.4.21.109 medulla oblongata skin Mus musculus
-
3.4.21.109 oral mucosa oral cavity Mus musculus
-
3.4.21.109 oxyntic cell glandular stomach Mus musculus
-
3.4.21.109 pancreatic islet pancreas Mus musculus
-
3.4.21.109 parotid gland duct epithelium
-
Mus musculus
-
3.4.21.109 renal distal tubule kidney Mus musculus
-
3.4.21.109 renal proximal tubule kidney Mus musculus
-
3.4.21.109 sebaceous gland skin Mus musculus
-
3.4.21.109 stratum granulosum cerebelli skin Mus musculus
-
3.4.21.109 sublingual gland duct epithelium
-
Mus musculus
-
3.4.21.109 submandibular gland duct epithelium
-
Mus musculus
-
3.4.21.109 surface epithelium colon, uterus Mus musculus
-
3.4.21.109 THP-1 cell
-
Homo sapiens
-
3.4.21.109 thymic medullary epithelium
-
Mus musculus
-
3.4.21.109 tongue epithelium oral cavity Mus musculus
-
3.4.21.109 uterine gland uterus Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.109 Glu-Gly-Arg-p-nitroanilide + H2O substrate activity assay Homo sapiens ?
-
?
3.4.21.109 pro-urokinase-type plasminogen activator + H2O
-
Mus musculus ?
-
?
3.4.21.109 pro-urokinase-type plasminogen activator + H2O
-
Homo sapiens ?
-
?
3.4.21.109 prostatin + H2O
-
Mus musculus ?
-
?
3.4.21.109 prostatin + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.109 matriptase
-
Mus musculus
3.4.21.109 matriptase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.109 37
-
activity, inhibition assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.109 8
-
activity, inhibition assay Homo sapiens