Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Witola, W.H.; El Bissati, K.; Pessi, G.; Xie, C.; Roepe, P.D.; Ben Mamoun, C.
    Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the SDPM pathway and severe growth and survival defects (2008), J. Biol. Chem., 283, 27636-27643.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.103 additional information construction of knockout mutants, disruption of the PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase phosphoethanolamine-methyltransferase, SDPM, pathway and severe growth and survival defects, phenotype, overview Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.103 additional information Plasmodium falciparum the transmethylation of phosphatidylethanolamine plays a role in the biosynthesis of phosphatidylcholine via the serine-decarboxylase phosphoethanolamine-methyltransferase pathway, which is important in the parasite's growth and survival, overview ?
-
 ?
2.1.1.103 S-adenosyl-L-methionine + phosphoethanolamine Plasmodium falciparum the enzyme catalyzes one step of the the three-step methylation of phosphoethanolamine to phosphocholine S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.103 Plasmodium falciparum
-
-
-
2.1.1.103 Plasmodium falciparum
-
 gene PfPMT
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.103 additional information the transmethylation of phosphatidylethanolamine plays a role in the biosynthesis of phosphatidylcholine via the serine-decarboxylase phosphoethanolamine-methyltransferase pathway, which is important in the parasite's growth and survival, overview Plasmodium falciparum ?
-
 ?
2.1.1.103 S-adenosyl-L-methionine + ethanolamine phosphate
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + N-methylethanolamine phosphate
-
 ?
2.1.1.103 S-adenosyl-L-methionine + phosphoethanolamine
-
 Plasmodium falciparum S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
 ?
2.1.1.103 S-adenosyl-L-methionine + phosphoethanolamine the enzyme catalyzes one step of the the three-step methylation of phosphoethanolamine to phosphocholine Plasmodium falciparum S-adenosyl-L-homocysteine + methylethanolamine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.103 phosphoethanolamine methyltransferase
-
 Plasmodium falciparum
2.1.1.103 PMT
-
 Plasmodium falciparum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.103 30
-
 assay at Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.103 8.6
-
 assay at Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.103 S-adenosyl-L-methionine
-
 Plasmodium falciparum

General Information

EC Number General Information Comment Organism
2.1.1.103 malfunction knock-out of the PMT gene encoding the phosphoethanolamine methyltransferase enzyme completely abrogates the biosynthesis of phosphatidylcholine via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway, loss of PMT results in significant defects in parasite growth, multiplication, and viability, suggesting that this gene plays an important role in the pathogenesis of intraerythrocytic Plasmodium parasites Plasmodium falciparum