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Literature summary extracted from
- Intermediate phosphorylation reactions in the mechanism of ATP utilization by the copper ATPase (CopA) of Thermotoga maritima (2008), J. Biol. Chem., 283, 22541-22549.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.2.2.8 | expressed in Escherichia coli | Thermotoga maritima |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | H479Q | the mutant is unable to utilize ATP, whereas phosphorylation by phosphate is retained | Thermotoga maritima |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.8 | Cu+ | Cu+ binding to the N-metal binding domain is required to produce an active conformation of the enzyme, whereby additional Cu+ bound to an alternate (transmembrane transport) site initiates faster cycles | Thermotoga maritima |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.8 | ATP + H2O + Cu+[side 1] | Thermotoga maritima | - |
ADP + phosphate + Cu+[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.8 | Thermotoga maritima | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | phosphoprotein | - |
Thermotoga maritima |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.2.2.8 | - |
Thermotoga maritima |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.8 | ATP + H2O + Cu+[side 1] | - |
Thermotoga maritima | ADP + phosphate + Cu+[side 2] | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.8 | CopA | - |
Thermotoga maritima |
| 7.2.2.8 | copper ATPase | - |
Thermotoga maritima |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.8 | 60 | - |
- |
Thermotoga maritima |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.8 | 6 | - |
- |
Thermotoga maritima |
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Release 2023.1 (January 2023)
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