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Literature summary extracted from

  • Beretta, M.; Gruber, K.; Kollau, A.; Russwurm, M.; Koesling, D.; Goessler, W.; Keung, W.M.; Schmidt, K.; Mayer, B.
    Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases (2008), J. Biol. Chem., 283, 17873-17880.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.3 into the vector pT7.7 for expression in Escherichia coli BL21DE3 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 Chloral hydrate
-
 Homo sapiens
1.2.1.3 daidzin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.3 0.00033
-
 acetaldehyde
-
 Homo sapiens
1.2.1.3 0.2
-
 acetaldehyde
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytosol
-
 Homo sapiens 5829
-
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.3 by p-hydroxyacetophenone affinity chromatography Homo sapiens
1.2.1.3 by p-hydroxyacetophenone affinity chromatography and gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 0.00018
-
 conversion of glycerol trinitrate to 1,3-glycerol dinitrate Homo sapiens
1.2.1.3 0.00066
-
 conversion of glycerol trinitrate to 1,3-glycerol dinitrate Homo sapiens
1.2.1.3 0.003
-
 conversion of glycerol trinitrate to 1,2-glycerol dinitrate Homo sapiens
1.2.1.3 0.009
-
 conversion of glycerol trinitrate to 1,2-glycerol dinitrate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O activity assay Homo sapiens acetate + NADH + H+
-
 ?
1.2.1.3 glyceryl trinitrate + NADH + H+
-
 Homo sapiens 1,2-glyceryl dinitrate + nitrite + NAD+
-
 ?
1.2.1.3 glyceryl trinitrate + NADH + H+
-
 Homo sapiens 1,3-glyceryl dinitrate + nitrite + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 aldehyde dehydrogenase 1
-
 Homo sapiens
1.2.1.3 aldehyde dehydrogenase 2
-
 Homo sapiens
1.2.1.3 ALDH1
-
 Homo sapiens
1.2.1.3 ALDH2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.3 25
-
 activity assay Homo sapiens
1.2.1.3 37
-
 incubation of ALDH with 14C-labeled nitroglycerin Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 7.4
-
 incubation of ALDH with 14C-labeled nitroglycerin Homo sapiens
1.2.1.3 9
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens