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Literature summary extracted from

  • Walker, C.S.; Shetty, R.P.; Clark, K.; Kazuko, S.G.; Letsou, A.; Olivera, B.M.; Bandyopadhyay, P.K.
    On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila (2001), J. Biol. Chem., 276, 7769-7774.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.90 additional information Drosophila melanogaster one of the most distinctive of the extracellular post-translational modifications is the vitamin K-dependent gamma-carboxylation of glutamate residues to give gamma-carboxyglutamate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Drosophila melanogaster Q9W0C4 schematic of amino acid homology between human and the Drosophila gamma-glutamyl carboxylase shown
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.90 S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.90 conantokin G + CO2 + O2 + vitamin K hydroquinone poorly carboxylated Drosophila melanogaster ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 FLEEL + CO2 + O2 + vitamin K hydroquinone
-
 Drosophila melanogaster ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 GKDRLTQMKRILKQRGNKARGEEELY + CO2 + O2 + vitamin K hydroquinone
-
 Drosophila melanogaster ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 L-glutamate + CO2 + O2 + vitamin K hydroquinone
-
 Drosophila melanogaster gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?
4.1.1.90 additional information one of the most distinctive of the extracellular post-translational modifications is the vitamin K-dependent gamma-carboxylation of glutamate residues to give gamma-carboxyglutamate Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 gamma-glutamyl carboxylase
-
 Drosophila melanogaster
4.1.1.90 glutamate carboxylase
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.90 vitamin K phytonadione Drosophila melanogaster