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Literature summary extracted from

  • Wu, S.M.; Mutucumarana. V.P.; Geromanos, S.; Stafford, D.W.
    The propeptide binding site of the bovine gamma-glutamyl carboxylase (1997), J. Biol. Chem., 272, 11718-11722.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.90 endoplasmic reticulum
-
 Bos taurus 5783
-
4.1.1.90 membrane integral membrane protein Bos taurus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.1.1.90 94000
-
 SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.90 additional information Bos taurus enzyme required for the posttranslational modification of vitamin K-dependent proteins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Bos taurus Q07175
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.90 4-benzoyl-L-phenylalanine + CO2 + O2 + vitamin K hydroquinone BPA Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 CDADWVEGYSMEYLSR + CO2 + O2 + vitamin K hydroquinone CDADWVEGYSMEYLSR Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 CGRPSLEQLAQEVTYA + CO2 + O2 + vitamin K hydroquinone CGRPSLEQLAQEVTYA Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 L-glutamate + CO2 + O2 + vitamin K hydroquinone vitamin K epoxide must be recycled to vitamin K hydroquinone by the enzyme epoxide reductase for the reaction to continue Bos taurus gamma-carboxy L-glutamate + vitamin K epoxide + H2O
-
 ?
4.1.1.90 additional information enzyme required for the posttranslational modification of vitamin K-dependent proteins Bos taurus ?
-
 ?
4.1.1.90 pro-FIX19 + CO2 + O2 + vitamin K hydroquinone pro-FIX19: peptide comprising residues of human factor IX AVFLDHENANKILNRPKRY Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 pro-FIX19-16BPA + CO2 + O2 + vitamin K hydroquinone pro-FIX19-16BPA: peptide comprising residues TVBLDHENANKILNRPKRY Bos taurus ? + vitamin K epoxide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.90 ? x * 94000, SDS-PAGE Bos taurus
4.1.1.90 More binding site in the carboxyl half of the gamma-glutamyl carboxylase. Carboxylase may be cleaved by trypsin into an amino-terminal 30 kDa and a carboxyl-terminal 60 kDa fragment joined by disulfide bond(s), and the propeptide binds to the 60 kDa fragment Bos taurus

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 gamma-glutamyl carboxylase
-
 Bos taurus
4.1.1.90 glutamate carboxylase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.90 vitamin K
-
 Bos taurus