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Literature summary extracted from

  • Hirakawa, H.; Sawada, H.; Yamahama, Y.; Takikawa, S.; Shintaku, H.; Hara, A.; Mase, K.; Kondo, T.; Iino, T.
    Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues (2009), J. Biochem., 146, 51-60.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 N-acetylserotonin activity is completely inhibited by the addition of 0.5 mM N-acetylserotonin Homo sapiens
1.1.1.153 N-acetylserotonin activity is completely inhibited by the addition of 0.5 mM N-acetylserotonin Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Homo sapiens
-
-
-
1.1.1.153 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 liver
-
Mus musculus
-
1.1.1.153 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+
-
Mus musculus 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
?
1.1.1.153 6-pyruvoyl tetrahydropterin + NADPH + H+
-
Homo sapiens 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
?
1.1.1.153 sepiapterin + NADPH + H+
-
Mus musculus 7,8-dihydrobiopterin + NADP+
-
?
1.1.1.153 sepiapterin + NADPH + H+
-
Homo sapiens 7,8-dihydrobiopterin + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.153 AKR1B1
-
Mus musculus
1.1.1.153 SPR
-
Mus musculus
1.1.1.153 SPR
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
Mus musculus
1.1.1.153 NADPH
-
Homo sapiens