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Literature summary extracted from

  • Graupner, M.; Xu, H.; White, R.H.
    The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin (2002), J. Bacteriol., 184, 1952-1957.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.302 overexpressed in Escherichia coli Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ Methanosarcina thermophila step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ Methanosarcina thermophila step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
1.1.1.302 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ Methanocaldococcus jannaschii step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
1.1.1.302 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ Methanocaldococcus jannaschii step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.302 Methanocaldococcus jannaschii
-
-
-
1.1.1.302 Methanosarcina thermophila
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanosarcina thermophila 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanosarcina thermophila 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
1.1.1.302 2,5-diamino-6-(1-D-ribosylamino)-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ NADPH and NADH function equally well as reductant Methanosarcina thermophila 2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
1.1.1.302 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NAD+
-
 ?
1.1.1.302 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate + NADPH + H+ step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate + NADP+
-
 ?
1.1.1.302 additional information the enzyme does not catalyze the pyrimidine nucleotide-dependent reduction of 5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione 5'-phosphate Methanocaldococcus jannaschii ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.302 MJ0671
-
 Methanocaldococcus jannaschii
1.1.1.302 MJ0671 pyrimidine reductase
-
 Methanocaldococcus jannaschii

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.302 NADH NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii
1.1.1.302 NADH NADPH and NADH function equally well as reductant Methanosarcina thermophila
1.1.1.302 NADPH NADPH and NADH function equally well as reductant Methanocaldococcus jannaschii
1.1.1.302 NADPH NADPH and NADH function equally well as reductant Methanosarcina thermophila