Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Boettcher, T.; Sieber, S.A.
    Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus (2008), J. Am. Chem. Soc., 130, 14400-14401.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.92 drug development synthetic beta-lactones as novel inhibitors for specific and selective targeting of the key virulence regulator ClpP Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.92 3-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one shows stronger inhibitory effect Staphylococcus aureus
3.4.21.92 3-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one exerts the weakest effect on peptidase activity Staphylococcus aureus
3.4.21.92 3-butyl-4-(pent-4-ynyl)oxetan-2-one shows stronger inhibitory effect Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.92 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.92 ClpP
-
 Staphylococcus aureus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.92 0.004
-
 3-(4-methoxyphenyl)-4-(pent-4-ynyl)oxetan-2-one
-
 Staphylococcus aureus
3.4.21.92 0.006
-
 3-butyl-4-(pent-4-ynyl)oxetan-2-one
-
 Staphylococcus aureus
3.4.21.92 0.031
-
 3-(non-8-ynyl)-4-(pent-4-ynyl)oxetan-2-one
-
 Staphylococcus aureus