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Literature summary extracted from

  • Jeong, S.H.; Ryu, Y.B.; Curtis-Long, M.J.; Ryu, H.W.; Baek, Y.S.; Kang, J.E.; Lee, W.S.; Park, K.H.
    Tyrosinase inhibitory polyphenols from roots of Morus lhou (2009), J. Agric. Food Chem., 57, 1195-1203.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone competitive inhibitor Agaricus bisporus
1.14.18.1 albafuran A
-
 Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus
1.14.18.1 kuwanon A
-
 Agaricus bisporus
1.14.18.1 kuwanon E competitive inhibitor Agaricus bisporus
1.14.18.1 kuwanon U
-
 Agaricus bisporus
1.14.18.1 moracin M competitive inhibitor Agaricus bisporus
1.14.18.1 moracin N competitive inhibitor Agaricus bisporus
1.14.18.1 moracinoside M competitive inhibitor Agaricus bisporus
1.14.18.1 morusinol
-
 Agaricus bisporus
1.14.18.1 neocyclomorusin competitive inhibitor Agaricus bisporus
1.14.18.1 norartocarpetin competitive inhibitor Agaricus bisporus
1.14.18.1 steppogenin competitive inhibitor Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 polyphenoloxidase
-
 Agaricus bisporus
1.14.18.1 PPO
-
 Agaricus bisporus
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0012
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus norartocarpetin
1.14.18.1 0.0013
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus steppogenin
1.14.18.1 0.0074
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin M
1.14.18.1 0.0163
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kojic acid
1.14.18.1 0.0265
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus steppogenin
1.14.18.1 0.0442
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus 8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
1.14.18.1 0.0475
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon E
1.14.18.1 0.0646
-
 using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin M
1.14.18.1 0.0825
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracinoside M
1.14.18.1 0.0985
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus albafuran A
1.14.18.1 0.1274
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus neocyclomorusin
1.14.18.1 0.1318
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon A
1.14.18.1 0.1603
-
 using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin N
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus norartocarpetin
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon A
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon E
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon U
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus 8-isoprenyl-5'-geranyl-5,7,2',4'-tetrahydroxy flavanone
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus morusinol
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus neocyclomorusin
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracin N
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus albafuran A
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-DOPA as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus moracinoside M
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus kuwanon U
1.14.18.1 0.2
-
 IC50 above 0.2 mM, using L-tyrosine as substrate, in 0.25 M phosphate buffer (pH 6.8), at 30°C Agaricus bisporus morusinol