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Literature summary extracted from

  • Giannarelli, C.; Virdis, A.; De Negri, F.; Duranti, E.; Magagna, A.; Ghiadoni, L.; Salvetti, A.; Taddei, S.
    Tissue-type plasminogen activator release in healthy subjects and hypertensive patients: relationship with beta-adrenergic receptors and the nitric oxide pathway (2008), Hypertension, 52, 314-321.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.68 epinephrine intrabrachial infusion of epinephrine (0.1 to 0.3 microg/100 ml per minute) induces greater t-PA release in normotensive subjects as compared with essential hypertensive patients Homo sapiens
3.4.21.68 isoproterenol intrabrachial isoproterenol (0.03 mcirog/100 ml per minute) induces a significant increase in t-PA release, an effect blunted by NG-monomethyl-L-arginine Homo sapiens
3.4.21.68 additional information adrenergic-induced t-PA release is mediated by beta-adrenoreceptors via a mechanism involving the NO pathway. No significant difference in net t-PA release after ouabain infusion. No significant increase in t-PA release during sodium nitroprusside infusion Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.68 additional information inhibition of NO synthase with NG-monomethyl-L-arginine (100 microg/100 ml per minute) infusion blunts epinephrine-induced t-PA release in normotensive subjects but not in essential hypertensive patients. In normotensive subjects, t-PA release by epinephrine is not affected by phentolamine coinfusion Homo sapiens
3.4.21.68 propanolol in normotensive subjects, t-PA release by epinephrine is abolished in the presence of propanolol (10 microg/100 ml per minute). In essential hypertensive patients, the response to isoproterenol is impaired as compared with normotensive subjects and is unaffected by NG-monomethyl-L-arginine coinfusion Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 endothelial cell arterial and venous concentrations of t-PA are significantly lower in hypertensive patients than in normotensive subjects Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 t-PA
-
 Homo sapiens
3.4.21.68 Tissue-type plasminogen activator
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 Homo sapiens