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Literature summary extracted from

  • Shintani, T.; Iwabuchi, T.; Soga, T.; Kato, Y.; Yamamoto, T.; Takano, N.; Hishiki, T.; Ueno, Y.; Ikeda, S.; Sakuragawa, T.; Ishikawa, K.; Goda, N.; Kitagawa, Y.; Kajimura, M.; Matsumoto, K.; Suematsu, M.
    Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion (2009), Hepatology, 49, 141-150.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.22
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.22 carbon monoxide binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity Mus musculus
4.2.1.22 carbon monoxide binds to the prosthetic heme, stabilizing 6-coordinated CO-Fe(II)-histidine complex to block the activity Rattus norvegicus
4.2.1.22 additional information not inhibited by nitric oxide Mus musculus
4.2.1.22 additional information not inhibited by nitric oxide Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.22 Mus musculus
-
-
-
4.2.1.22 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.22
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.22 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.22 cysteine + ?
-
 Mus musculus H2S + ?
-
 ?
4.2.1.22 cysteine + ?
-
 Rattus norvegicus H2S + ?
-
 ?
4.2.1.22 L-serine + L-homocysteine
-
 Mus musculus L-cystathionine + H2O
-
 ?
4.2.1.22 L-serine + L-homocysteine
-
 Rattus norvegicus L-cystathionine + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.22 CBS
-
 Mus musculus
4.2.1.22 CBS
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.2.1.22 heme
-
 Mus musculus
4.2.1.22 heme
-
 Rattus norvegicus
4.2.1.22 pyridoxal 5'-phosphate
-
 Mus musculus
4.2.1.22 pyridoxal 5'-phosphate
-
 Rattus norvegicus