Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lagarou, A.; Mohd-Sarip, A.; Moshkin, Y.; Chalkley, G.; Bezstarosti, K.; Demmers, J.; Verrijzer, C.
    dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing (2008), Genes Dev., 22, 2799-2810.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 Drosophila melanogaster removal of histone H3 Lys36 dimethylation is coupled to histone H2A monoubiquitinylation, overview [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.27 Drosophila melanogaster Q9VHH9 gene dkkdm2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2
-
 Drosophila melanogaster [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?
1.14.11.27 [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 removal of histone H3 Lys36 dimethylation is coupled to histone H2A monoubiquitinylation, overview Drosophila melanogaster [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.27 dKDM2
-
 Drosophila melanogaster
1.14.11.27 dRAF
-
 Drosophila melanogaster
1.14.11.27 [histone-H3]-lysine-36 demethylase 1
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
1.14.11.27 metabolism dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group gene silencing as a mode of histone crosstalk, the enzyme acts as part of the dRING-associated factor, dRAF, a Polycomb group silencing complex harboring also the histone H2A ubiquitin ligase dRING, Posterior sex combs and the F-box protein, overview. dRAF and PCR1 are separtate Polycomb group complexes, dKDM2 and PRC1 control overlapping transcriptomes, mechanisms, overview Drosophila melanogaster
1.14.11.27 physiological function in vivo, the enzyme cooperates with Polycomb but antagonizes gene activation by particular trxG methyltransferases, gene dkdm2 is an enhancer of Polycomb but a suppressor of histone methyltransferases trx and ash1 Drosophila melanogaster