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Literature summary extracted from

  • Labrie, V.; Wang, W.; Barger, S.W.; Baker, G.B.; Roder, J.C.
    Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice (2009), Genes Brain Behav., 9, 11-25.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.4.3.3 pharmacology diminished DAO activity and elevations in D-serine may serve as an effective therapeutic intervention for the treatment of psychiatric symptoms Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 genotyping Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.3 D481N Grin1D481N mice show deficits in sociability, prolonged latent inhibition, enhanced startle reactivity and impaired spatial memory Mus musculus
1.4.3.3 G181R the hypofunctional Dao1G181R mutation elevates brain levels of D-serine, but alone it does not affect performance in the behavioral measures Mus musculus
1.4.3.3 G181R/D481N compared to animals with only the Grin1D481N mutation, mice with both the Dao1G181R and Grin1D481N mutations display an improvement in social approach and spatial memory retention, as well as a reversal of abnormally persistent latent inhibition and a partial normalization of startle responses Mus musculus
1.4.3.3 additional information long-term increases in the brain levels of the endogenous N-methyl-D-aspartate receptor, NMDAR, glycine site agonist D-serine, through the genetic inactivation of its catabolic enzyme D-amino acid oxidase in mice Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-serine + H2O + O2 Mus musculus
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Mus musculus P18894
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-serine + H2O + O2
-
 Mus musculus 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.4.3.3 malfunction increased level of D-serine resulting from decreased catalysis correct the performance of mice with deficient NMDAR glycine site activation in behavioral tasks relevant to the negative and cognitive symptoms of schizophrenia Mus musculus