Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Soriani, F.M.; Kress, M.R.; Fagundes de Gouvea, P.; Malavazi, I.; Savoldi, M.; Gallmetzer, A.; Strauss, J.; Goldman, M.H.; Goldman, G.H.
    Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB) (2009), Fungal Genet. Biol., 46, 410-417.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Aspergillus nidulans
-
-
-
1.8.4.12 Aspergillus nidulans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form of L-methionine sulfoxide Aspergillus nidulans L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin MsrB is specific for the R-form of L-methionine sulfoxide Aspergillus nidulans L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Aspergillus nidulans
1.8.4.11 MsrA
-
 Aspergillus nidulans
1.8.4.12 methionine sulfoxide reductase B
-
 Aspergillus nidulans
1.8.4.12 MsrB
-
 Aspergillus nidulans

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Aspergillus nidulans
1.8.4.12 thioredoxin
-
 Aspergillus nidulans

General Information

EC Number General Information Comment Organism
1.8.4.11 physiological function both single and double inactivation mutants are viable, but more sensitive to oxidative stress agents as hydrogen peroxide, paraquat, and ultraviolet light. These strains also accumulate more carbonylated proteins when exposed to hydrogen peroxide indicating that MsrA is an active player in the protection of the cellular proteins from oxidative stress damage Aspergillus nidulans
1.8.4.12 physiological function both single and double inactivation mutants are viable, but more sensitive to oxidative stress agents as hydrogen peroxide, paraquat, and ultraviolet light. These strains also accumulate more carbonylated proteins when exposed to hydrogen peroxide indicating that MsrB is an active player in the protection of the cellular proteins from oxidative stress damage Aspergillus nidulans