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Literature summary extracted from

  • Shin, S.W.; Oh, C.J.; Kil, I.S.; Park, J.W.
    Glutathionylation regulates cytosolic NADP+-dependent isocitrate dehydrogenase activity (2009), Free Radic. Res., 43, 409-416.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.42 expressed in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.42 C269S activity of the C269S mutant is not affected by glutathione disulfide and no glutathionylated IDPc is observed with 5 mM glutathione disulfide confirming that Cys269 is a target of IDPc glutathionylation Homo sapiens
1.1.1.42 C379S glutathionylation of the C379S mutant is similar to that of wild type enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 Diamide
-
Homo sapiens
1.1.1.42 glutathione disulfide incubation with 5 mM glutathione disulfide for 30 min completely eliminates activity Homo sapiens
1.1.1.42 additional information 5 mM glutathione does not noticeably inhibit IDPc activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.42 45000
-
SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.42 glutathionylation Cys269 of IDPc is a target for S-glutathionylation, this modification is reversed by dithiothreitol as well as enzymatically by cytosolic glutaredoxin in the presence of glutathione. Glutathionylated IDPc is significantly less susceptible than native protein to peptide fragmentation by reactive oxygen species and proteolytic digestion. Glutathionylation may play a protective role in the degradation of protein through the structural alterations of IDPc. Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.42 Ni-NTA column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + CO2 + NADPH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 cytosolic NADP+-dependent isocitrate dehydrogenase
-
Homo sapiens
1.1.1.42 ICDH
-
Homo sapiens
1.1.1.42 IDPc
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
Homo sapiens