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Literature summary extracted from

  • Lee, S.M.; Park, S.Y.; Shin, S.W.; Kil, I.S.; Yang, E.S.; Park, J.W.
    Silencing of cytosolic NADP(+)-dependent isocitrate dehydrogenase by small interfering RNA enhances the sensitivity of HeLa cells toward staurosporine (2009), Free Radic. Res., 43, 165-173.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.42 expressed in HeLa cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 additional information transfection of HeLa cells with an IDPc small interfering RNA decreases activity of IDPc by 80%, enhancing the susceptibility of staurosporine-induced apoptosis reflected by DNA fragmentation, cellular redox status and the modulation of apoptotic marker proteins Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 cytosol
-
Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.42 isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + CO2 + NADPH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.42 cytosolic NADP(+)-dependent isocitrate dehydrogenase
-
Homo sapiens
1.1.1.42 ICDH
-
Homo sapiens
1.1.1.42 IDPc
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.42 NADP+
-
Homo sapiens