BRENDA - Enzyme Database

An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation

Batinic-Haberle, I.; Benov, L.T.; Free Radic. Res. 42, 618-624 (2008)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
desferroxamine
-
Escherichia coli
1.1.1.42
desferroxamine
-
Rattus norvegicus
1.1.1.42
Diethylenetriaminepentaacetic acid
-
Escherichia coli
1.1.1.42
Diethylenetriaminepentaacetic acid
-
Rattus norvegicus
1.1.1.42
manganese(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin
a superoxide dismutase mimic, ICD is inactivated by superoxide, but the inactivated enzyme is replaced by de novo protein synthesis
Escherichia coli
1.1.1.42
manganese(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin
a superoxide dismutase mimic
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Escherichia coli
-
-
-
1.1.1.42
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
heart
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
698056
Escherichia coli
2-oxoglutarate + CO2 + NADPH
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
698056
Rattus norvegicus
2-oxoglutarate + CO2 + NADPH
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Escherichia coli
1.1.1.42
NADP+
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Escherichia coli
1.1.1.42
NADP+
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
desferroxamine
-
Escherichia coli
1.1.1.42
desferroxamine
-
Rattus norvegicus
1.1.1.42
Diethylenetriaminepentaacetic acid
-
Escherichia coli
1.1.1.42
Diethylenetriaminepentaacetic acid
-
Rattus norvegicus
1.1.1.42
manganese(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin
a superoxide dismutase mimic, ICD is inactivated by superoxide, but the inactivated enzyme is replaced by de novo protein synthesis
Escherichia coli
1.1.1.42
manganese(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin
a superoxide dismutase mimic
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
heart
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
698056
Escherichia coli
2-oxoglutarate + CO2 + NADPH
-
-
-
?
1.1.1.42
isocitrate + NADP+
-
698056
Rattus norvegicus
2-oxoglutarate + CO2 + NADPH
-
-
-
?