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Literature summary extracted from

  • Dolai, S.; Yadav, R.K.; Pal, S.; Adak, S.
    Leishmania major ascorbate peroxidase overexpression protects cells against reactive oxygen species-mediated cardiolipin oxidation (2008), Free Radic. Biol. Med., 45, 1520-1529.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.11.1.11 H2O2
-
Leishmania major

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.11 into the vector pXG-B2863 for transfection of Leishmania major cells Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.11 azide
-
Leishmania major

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.11 mitochondrial intermembrane space
-
Leishmania major 5758
-
1.11.1.11 mitochondrion
-
Leishmania major 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.11.1.11 30000
-
determined by SDS-PAGE and Western blot analysis, LmAPX in the intermembrane space of the mitochondrial inner membrane is appr. 3.6 kDa shorter than the full-length gene Leishmania major

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.11 L-ascorbate + H2O2 Leishmania major
-
dehydroascorbate + H2O
-
?
1.11.1.11 L-ascorbate + H2O2 Leishmania major 5ASKH
-
dehydroascorbate + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.11 Leishmania major
-
-
-
1.11.1.11 Leishmania major 5ASKH
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.11 mitochondria are prepared and fractionated Leishmania major

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.11 dihydrorhodamine 123 + H2O2 assay, peroxidase substrate Leishmania major ?
-
?
1.11.1.11 dihydrorhodamine 123 + H2O2 assay, peroxidase substrate Leishmania major 5ASKH ?
-
?
1.11.1.11 L-ascorbate + H2O2
-
Leishmania major dehydroascorbate + H2O
-
?
1.11.1.11 L-ascorbate + H2O2
-
Leishmania major 5ASKH dehydroascorbate + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.11 ascorbate peroxidase
-
Leishmania major
1.11.1.11 LmAPX
-
Leishmania major

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.11.1.11 30
-
peroxidase assay Leishmania major

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.11 heme
-
Leishmania major

Expression

EC Number Organism Comment Expression
1.11.1.11 Leishmania major expression of LmAPX is increased when cells are treated with exogenous H2O2 up