Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Guo, Z.; Ran, Q.; Roberts, L.J.; Zhou, L.; Richardson, A.; Sharan, C.; Wu, D.; Yang, H.
    Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice (2008), Free Radic. Biol. Med., 44, 343-352.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.11.1.12 medicine overexpression of GPx4 inhibits the development of atherosclerosis by decreasing lipid peroxidation and inhibiting the sensitivity of vascular cells to oxidized lipids Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.12 transgenic mice overexpressing human GPx4 are generated Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.11.1.12 selenium
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.11.1.12 21000
-
 20 to 22 kDa Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.12 glutathione + a lipid hydroperoxide Homo sapiens
-
 glutathione disulfide + lipid + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.12 aorta transgenic mouse Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.12 glutathione + a lipid hydroperoxide
-
 Homo sapiens glutathione disulfide + lipid + H2O
-
 ?
1.11.1.12 glutathione + phosphatidylcholine hydroperoxide activity assay Homo sapiens ?
-
 ?
1.11.1.12 additional information GPx4 can react with H2O2 and a wide range of lipid hydroperoxides including oxidized phospholipids and cholesterol hydroperoxides Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.12 monomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.11.1.12 glutathione peroxidase-4
-
 Homo sapiens
1.11.1.12 GPx4
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.11.1.12 7.4
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.12 glutathione
-
 Homo sapiens