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Literature summary extracted from

  • Gumy, C.; Thurnbichler, C.; Aubry, E.M.; Balazs, Z.; Pfisterer, P.; Baumgartner, L.; Stuppner, H.; Odermatt, A.; Rollinger, J.M.
    Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines (2009), Fitoterapia, 80, 200-205.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 glycyrrhetinic acid 11beta-HSD1 shows 21% residual activity at 0.01 mM, 11beta-HSD2 shows 16% residual activity at 0.01 mM Homo sapiens
1.1.1.146 additional information leaf extracts of Eriobotrya japonica preferentially inhibit 11beta-HSD1 over 11beta-HSD2, extracts of roasted but not native coffee beans preferentially inhibit 11beta-HSD1 over 11beta-HSD2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+ the reaction is catalysed by 11beta-HSD2 Homo sapiens cortisone + NADPH
-
 ?
1.1.1.146 cortisone + NADPH + H+ reaction is catalysed by 11beta-HSD1 Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-HSD2
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Homo sapiens
1.1.1.146 NADPH
-
 Homo sapiens