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Literature summary extracted from

  • Medici, R.; Lewkowicz, E.S.; Iribarren, A.M.
    Arthrobacter oxydans as a biocatalyst for purine deamination (2008), FEMS Microbiol. Lett., 289, 20-26.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.4.3 drug development because these enzymes play an important role in nucleotide metabolism, they are relevant targets in anticancer and antibacterial therapies Pseudarthrobacter oxydans
3.5.4.4 drug development because these enzyme plays an important role in nucleotide metabolism, they are relevant targets in anticancer and antibacterial therapies Pseudarthrobacter oxydans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.3 guanine + H2O Pseudarthrobacter oxydans nucleotide metabolism xanthine + NH3
-
 ?
3.5.4.4 adenosine + H2O Pseudarthrobacter oxydans ADA, nucleotide metabolism inosine + NH3
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.3 Pseudarthrobacter oxydans
-
-
-
3.5.4.4 Pseudarthrobacter oxydans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.3 2,6-diaminopurine + H2O
-
 Pseudarthrobacter oxydans xanthine + NH3
-
 ?
3.5.4.3 2-amino-6-chloropurine + H2O
-
 Pseudarthrobacter oxydans 6-chloro-3,9-dihydro-2H-purin-2-one + NH3
-
 ?
3.5.4.3 2-amino-6-methoxypurine + H2O
-
 Pseudarthrobacter oxydans 6-methoxy-3,9-dihydro-2H-purin-2-one + NH3
-
 ?
3.5.4.3 guanine + H2O nucleotide metabolism Pseudarthrobacter oxydans xanthine + NH3
-
 ?
3.5.4.4 2',3'-dideoxyadenosine + H2O
-
 Pseudarthrobacter oxydans 2',3'-dideoxyinosine + NH3
-
 ?
3.5.4.4 2'-deoxyadenosine + H2O
-
 Pseudarthrobacter oxydans 2'-deoxyinosine + NH3
-
 ?
3.5.4.4 2,6-diaminopurine arabinoside + H2O
-
 Pseudarthrobacter oxydans arabinoguanosine + NH3
-
 ?
3.5.4.4 2,6-diaminopurine riboside + H2O
-
 Pseudarthrobacter oxydans guanosine + NH3
-
 ?
3.5.4.4 2,6-diaminopurine-2',3'-dideoxyriboside + H2O
-
 Pseudarthrobacter oxydans 2',3'-dideoxyguanosine + NH3
-
 ?
3.5.4.4 2,6-diaminopurine-2'-deoxyriboside + H2O
-
 Pseudarthrobacter oxydans 2'-deoxyguanosine + NH3
-
 ?
3.5.4.4 2-amino-6-chloropurine riboside + H2O
-
 Pseudarthrobacter oxydans guanosine + ?
-
 ?
3.5.4.4 2-amino-6-methoxypurine riboside + H2O
-
 Pseudarthrobacter oxydans guanosine + ?
-
 ?
3.5.4.4 adenosine + H2O ADA, nucleotide metabolism Pseudarthrobacter oxydans inosine + NH3
-
 ir
3.5.4.4 arabinoadenosine + H2O
-
 Pseudarthrobacter oxydans arabinoinosine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.3 GDA
-
 Pseudarthrobacter oxydans
3.5.4.3 guanine deaminase
-
 Pseudarthrobacter oxydans
3.5.4.4 ADA
-
 Pseudarthrobacter oxydans
3.5.4.4 adenosine deaminase
-
 Pseudarthrobacter oxydans

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.5.4.4 60
-
 ADA is still active when the reactions are carried out at 60°C Pseudarthrobacter oxydans