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Literature summary extracted from

  • Maillet, M.; Morris, D.; Gaudry, M.; Marquet, A.
    The active site region of the vitamin K-dependent carboxylase includes both the amino-terminal hydrophobic and carboxy-terminal hydrophilic domains of the protein (1997), FEBS Lett., 413, 1-6.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.90 additional information 15 min irradiation in the absence of peptide resulted in a 10% inactivation of the carboxylase Bos taurus
4.1.1.90 proFIX/PT28 (Bpa +4) presence of proFIX/PT28 (Bpa +4) or its iodinated derivative 56% inactivation is observed Bos taurus
4.1.1.90 TVFLDHENANKILNRPKRANTBLEEVRK the enzyme is photoirradiated on ice at 365 nm with TVFLDHENANKILNRPKRANTBLEEVRK, TVFLDHENANKILNRPKRYNTBLEEVRK and mono [127I]TVFLDHENANKILNRPKRYNTBLEEVRK for various times Bos taurus
4.1.1.90 TVFLDHENANKILNRPKRYNTBLEEVRK the enzyme is photoirradiated on ice at 365 nm with TVFLDHENANKILNRPKRANTBLEEVRK, TVFLDHENANKILNRPKRYNTBLEEVRK and mono [127I]TVFLDHENANKILNRPKRYNTBLEEVRK for various times. Presence of TVFLDHENANKILNRPKRYNTBLEEVRK or its iodinated derivative 80% inactivation is observed Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.90 0.0068
-
 TVFLDHENANKILNRPKRANTBLEEVRK carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.90 Bos taurus Q07175
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.90 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.90 FLEEV + CO2 + O2 + vitamin K hydroquinone
-
 Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 additional information photolabeling of Q-glutamyl carboxylase with Bpa peptides Bos taurus ?
-
 ?
4.1.1.90 proFIX 19 + CO2 + O2 + vitamin K hydroquinone proFIX 19, peptide sequence: TVFLDHENANKILNRPKRY Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 proFIX/PT28 + CO2 + O2 + vitamin K hydroquinone proFIX/PT28, peptide sequence: TVFLDHENANKILNRPKRANTFLEEVRK Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 TVFLDHENANKILNRPKRANTBLEEVRK + CO2 + O2 + vitamin K hydroquinone carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate Bos taurus ? + vitamin K epoxide + H2O
-
 ?
4.1.1.90 TVFLDHENANKILNRPKRYNTBLEEVRK + CO2 + O2 + vitamin K hydroquinone
-
 Bos taurus ? + vitamin K epoxide + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.90 More limited tryptic digestion of the carboxylase yields two disulfide-linked fragments with molecular masses of 30 and 60 kDa, corresponding to the amino and carboxy-terminal part of the gamma-glutamyl carboxylase Bos taurus

Synonyms

EC Number Synonyms Comment Organism
4.1.1.90 gamma-glutamyl carboxylase
-
 Bos taurus
4.1.1.90 glutamate carboxylase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.90 vitamin K
-
 Bos taurus