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Literature summary extracted from

  • Morgunova, E.; Illarionov, B.; Sambaiah, T.; Haase, I.; Bacher, A.; Cushman, M.; Fischer, M.; Ladenstein, R.
    Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis (2006), FEBS J., 273, 4790-4804.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.78 crystals are obtained in sitting drops by the vapour diffusion technique with the macroseeding procedure Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.78 1,3,7-trihydro-9-D-ribityl-2,4,8-purinetrione association constants and thermodynamic parameters of binding Mycobacterium tuberculosis
2.5.1.78 4-(6-chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-yl)butyl 1-phosphate association constants and thermodynamic parameters of binding Mycobacterium tuberculosis
2.5.1.78 5-(1,3,7-trihydro-9-d-ribityl-2,4,8-purinetrione-7-yl)1,1-difluoropentane-1-phosphate association constants and thermodynamic parameters of binding Mycobacterium tuberculosis
2.5.1.78 5-(1,3,7-trihydro-9-D-ribityl-2,4,8-purinetrione-7-yl)pentane1-phosphate association constants and thermodynamic parameters of binding Mycobacterium tuberculosis
2.5.1.78 6-(1,3,7-trihydro-9-d-ribityl-2,4,8-purinetrione-7-yl)hexane 1-phosphate association constants and thermodynamic parameters of binding Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.78 Mycobacterium tuberculosis
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