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Literature summary extracted from

  • Huellner, M.W.; Schrepfer, S.; Weyand, M.; Weiner, H.; Wimplinger, I.; Eschenhagen, T.; Rau, T.
    Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins (2008), FASEB J., 22, 2561-2568.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.3 medicine in human capacitance vessels ALDH2 is s a key enzyme for the biotransformation of the frequently used antianginal drug nitroglycerin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 1-ethoxycyclopropanol
-
 Homo sapiens
1.2.1.3 Chloral hydrate
-
 Homo sapiens
1.2.1.3 cyanamide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.3 57000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.3 an aldehyde + NAD+ + H2O Homo sapiens
-
 an acid + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 vein
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.3 0.00088
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 an aldehyde + NAD+ + H2O
-
 Homo sapiens an acid + NADH + H+
-
 ?
1.2.1.3 glyceryl trinitrate + NADH + H+
-
 Homo sapiens 1,2-glyceryl dinitrate + nitrite + NAD+
-
 ?
1.2.1.3 propanal + NAD+ + H2O activity assay Homo sapiens propanoic acid + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 aldehyde dehydrogenase type 2
-
 Homo sapiens
1.2.1.3 ALDH2
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.3 8.8
-
 activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens