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Literature summary extracted from

  • Hamming, I.; van Goor, H.; Turner, A.J.; Rushworth, C.A.; Michaud, A.A.; Corvol, P.; Navis, G.
    Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats (2008), Exp. Physiol., 93, 631-638.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 lisinopril treatment with 75 mg/l lisinopril significantly reduces renal ACE activity without affecting renal ACE2 activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 blood plasma
-
 Rattus norvegicus
-
3.4.15.1 kidney highly expressed in the kidney Rattus norvegicus
-
3.4.15.1 renal cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Rattus norvegicus hippuric acid + L-His-L-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Rattus norvegicus
3.4.15.1 angiotensin converting enzyme
-
 Rattus norvegicus