Literature summary extracted from

Cristovam, P.C.; Arnoni, C.P.; de Andrade, M.C.; Casarini, D.E.; Pereira, L.G.; Schor, N.; Boim, M.A.
ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells (2008), Exp. Biol. Med., 233, 1035-1043.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.39	additional information	high glucose causes a 3fold increase in chymase mRNA level	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.39	chymostatin	-	Homo sapiens
3.4.21.39	additional information	not inhibited by captopril	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.21.39	angiotensin I + H2O	Homo sapiens	-	angiotensin II + His-Leu	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.39	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.39	mesangial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.39	angiotensin I + H2O	-	Homo sapiens	angiotensin II + His-Leu	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.39	Chy	-	Homo sapiens

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Release 2023.1 (January 2023)