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Literature summary extracted from

  • Issandou, M.; Bouillot, A.; Brusq, J.M.; Forest, M.C.; Grillot, D.; Guillard, R.; Martin, S.; Michiels, C.; Sulpice, T.; Daugan, A.
    Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models (2009), Eur. J. Pharmacol., 618, 28-36.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 CP-24879 9% inhibition at 0.01 mM Homo sapiens
1.14.19.1 GSK-993 potent and orally available SCD1 inhibitor, almost complete inhibition at 0.01 mM Homo sapiens
1.14.19.1 GSK-993 potent and orally available SCD1 inhibitor Rattus norvegicus
1.14.19.1 trans-10,cis-12 conjugated linoleic acid 95% inhibition at 0.1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 microsome
-
 Homo sapiens
-
-
1.14.19.1 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens
-
-
-
1.14.19.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 Hep-G2 cell
-
 Homo sapiens
-
1.14.19.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + NADH + H+ + O2
-
 Homo sapiens oleoyl-CoA + NAD+ + H2O
-
 ?
1.14.19.1 stearoyl-CoA + NADH + H+ + O2
-
 Rattus norvegicus oleoyl-CoA + NAD+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
 Homo sapiens
1.14.19.1 SCD1
-
 Rattus norvegicus
1.14.19.1 stearoyl-CoA desaturase 1
-
 Homo sapiens
1.14.19.1 stearoyl-CoA desaturase 1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 NADH
-
 Homo sapiens
1.14.19.1 NADH
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.00017
-
 in 50 mM Tris-HCl, pH 7.4, at 25°C Homo sapiens GSK-993
1.14.19.1 0.00018
-
 in 50 mM Tris-HCl, pH 7.4, at 25°C Rattus norvegicus GSK-993