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Literature summary extracted from

  • Montenegro, M.F.; Pessa, L.R.; Tanus-Santos, J.E.
    Isoflavone genistein inhibits the angiotensin-converting enzyme and alters the vascular responses to angiotensin I and bradykinin (2009), Eur. J. Pharmacol., 607, 173-177.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 captopril
-
 Rattus norvegicus
3.4.15.1 genistein 0.003-0.3 mM genistein decreases the angiotensin-converting enzyme activity in blood plasma in a concentration-dependent manner; the isoflavone inhibits ACE in plasma and alters the vascular responses to angiotensin I and bradykinin, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.15.1 angiotensin I + H2O Rattus norvegicus i.e. DRVYIHPFHL angiotensin II + His-Leu i.e. DRVYIHPF ?
3.4.15.1 angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 bradykinin + H2O Rattus norvegicus
-
 L-Phe-L-Arg + L-Ser-L-Pro + L-Arg-L-Pro-L-Pro-Gly-L-Phe
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 blood plasma
-
 Rattus norvegicus
-
3.4.15.1 cardiovascular system
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O i.e. DRVYIHPFHL Rattus norvegicus angiotensin II + His-Leu i.e. DRVYIHPF ?
3.4.15.1 angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + L-His-L-Leu
-
 ?
3.4.15.1 bradykinin + H2O
-
 Rattus norvegicus L-Phe-L-Arg + L-Ser-L-Pro + L-Arg-L-Pro-L-Pro-Gly-L-Phe
-
 ?
3.4.15.1 hippuryl-L-His-L-Leu + H2O
-
 Rattus norvegicus hippuric acid + L-His-L-Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.15.1 ACE
-
 Rattus norvegicus
3.4.15.1 angiotensin converting enzyme
-
 Rattus norvegicus