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Literature summary extracted from
- Molecular cloning and functional characterization of cynomolgus monkey multidrug resistance-associated protein 2 (MRP2) (2008), Eur. J. Pharm. Sci., 35, 326-334.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | estrone glucuronide | the transport substrate stimulates the ATPase activity of MRP2 | Macaca fascicularis |  |
| 7.6.2.2 | Estrone sulfate | the transport substrate stimulates the ATPase activity of MRP2 | Macaca fascicularis | |
| 7.6.2.2 | methotrexate | the transport substrate stimulates the ATPase activity of MRP2 | Macaca fascicularis | |
| 7.6.2.2 | probenecid | the transport substrate stimulates the ATPase activity of MRP2 | Macaca fascicularis | |
| 7.6.2.2 | vinblastine | the transport substrate stimulates the ATPase activity of MRP2 | Macaca fascicularis | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.6.2.2 | MRP2, DNA and amino acid sequence determination and analysis, expression of MRP2 in Spodoptera frugiperda Sf9 cells | Macaca fascicularis |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | vanadate | inhibits the ATPase activity of MRP2 | Macaca fascicularis | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.6.2.2 | 0.0069 | - |
leukotriene C4/in | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.0108 | - |
vinblastine/in | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.0109 | - |
leukotriene C4/in | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
| 7.6.2.2 | 0.0115 | - |
2,4-dinitrophenyl-S-glutathione | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.0263 | - |
Estrone 3-sulfate | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.052 | - |
vinblastine/in | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
| 7.6.2.2 | 0.075 | - |
17beta-estradiol 17-(beta-D-glucuronide) | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.108 | - |
2,4-dinitrophenyl-S-glutathione | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
| 7.6.2.2 | 0.134 | - |
Estrone 3-sulfate | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
| 7.6.2.2 | 0.154 | - |
probenecid | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.195 | - |
17beta-estradiol 17-(beta-D-glucuronide) | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
| 7.6.2.2 | 0.282 | - |
methotrexate | pH 7.0, 37°C, recombinant MRP2 | Macaca fascicularis | |
| 7.6.2.2 | 0.351 | - |
probenecid | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
| 7.6.2.2 | 4.522 | - |
methotrexate | pH 7.0, 37°C, recombinant MRP2 | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.6.2.2 | membrane | - |
Homo sapiens | 16020 | - |
| 7.6.2.2 | membrane | - |
Macaca fascicularis | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | Mg2+ | required | Homo sapiens | |
| 7.6.2.2 | Mg2+ | required | Macaca fascicularis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + xenobiotic/in | Homo sapiens | - |
ADP + phosphate + xenobiotic/out | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic/in | Macaca fascicularis | - |
ADP + phosphate + xenobiotic/out | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | Homo sapiens | - |
- |
- |
| 7.6.2.2 | Macaca fascicularis | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | kidney | high expression level of MRP2 | Macaca fascicularis | - |
| 7.6.2.2 | additional information | tissue-specific expression of monkey MRP2, no expression in cerebrum and colon | Macaca fascicularis | - |
| 7.6.2.2 | small intestine | high expression level of MRP2 | Macaca fascicularis | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + 17beta-estradiol 17-(beta-D-glucuronide)/in | - |
Homo sapiens | ADP + phosphate + 17beta-estradiol 17-(beta-D-glucuronide)/out | - |
? | |
| 7.6.2.2 | ATP + H2O + 17beta-estradiol 17-(beta-D-glucuronide)/in | - |
Macaca fascicularis | ADP + phosphate + 17beta-estradiol 17-(beta-D-glucuronide)/out | - |
? | |
| 7.6.2.2 | ATP + H2O + estrone-3-sulfate/in | - |
Homo sapiens | ADP + phosphate + estrone-3-sulfate/out | - |
? | |
| 7.6.2.2 | ATP + H2O + estrone-3-sulfate/in | - |
Macaca fascicularis | ADP + phosphate + estrone-3-sulfate/out | - |
? | |
| 7.6.2.2 | ATP + H2O + leukotriene C4/in | - |
Homo sapiens | ADP + phosphate + leukotriene C4/out | - |
? | |
| 7.6.2.2 | ATP + H2O + leukotriene C4/in | - |
Macaca fascicularis | ADP + phosphate + leukotriene C4/out | - |
? | |
| 7.6.2.2 | ATP + H2O + methotrexate/in | - |
Homo sapiens | ADP + phosphate + methotrexate/out | - |
? | |
| 7.6.2.2 | ATP + H2O + methotrexate/in | - |
Macaca fascicularis | ADP + phosphate + methotrexate/out | - |
? | |
| 7.6.2.2 | ATP + H2O + probenecid/in | - |
Homo sapiens | ADP + phosphate + probenecid/out | - |
? | |
| 7.6.2.2 | ATP + H2O + probenecid/in | - |
Macaca fascicularis | ADP + phosphate + probenecid/out | - |
? | |
| 7.6.2.2 | ATP + H2O + S-2,4-dinitrophenylglutathione/in | - |
Homo sapiens | ADP + phosphate + S-2,4-dinitrophenylglutathione/out | - |
? | |
| 7.6.2.2 | ATP + H2O + S-2,4-dinitrophenylglutathione/in | - |
Macaca fascicularis | ADP + phosphate + S-2,4-dinitrophenylglutathione/out | - |
? | |
| 7.6.2.2 | ATP + H2O + vinblastine/in | - |
Homo sapiens | ADP + phosphate + vinblastine/out | - |
? | |
| 7.6.2.2 | ATP + H2O + vinblastine/in | - |
Macaca fascicularis | ADP + phosphate + vinblastine/out | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic/in | - |
Homo sapiens | ADP + phosphate + xenobiotic/out | - |
? | |
| 7.6.2.2 | ATP + H2O + xenobiotic/in | - |
Macaca fascicularis | ADP + phosphate + xenobiotic/out | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | MRP2 | - |
Homo sapiens |
| 7.6.2.2 | MRP2 | - |
Macaca fascicularis |
| 7.6.2.2 | multidrug resistance-associated protein 2 | - |
Homo sapiens |
| 7.6.2.2 | multidrug resistance-associated protein 2 | - |
Macaca fascicularis |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.2 | 37 | - |
assay at | Homo sapiens |
| 7.6.2.2 | 37 | - |
assay at | Macaca fascicularis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.2 | 7 | - |
assay at | Homo sapiens |
| 7.6.2.2 | 7 | - |
assay at | Macaca fascicularis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | ATP | - |
Homo sapiens | |
| 7.6.2.2 | ATP | - |
Macaca fascicularis | |
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