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Literature summary extracted from

  • Lee, K.H.; Ab Aziz, F.H.; Syahida, A.; Abas, F.; Shaari, K.; Israf, D.A.; Lajis, N.H.
    Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities (2009), Eur. J. Med. Chem., 44, 3195-3200.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 (1E,4E)-1,5-bis(2-fluoro-4-methoxyphenyl)penta-1,4-dien-3-one
-
 Agaricus bisporus
1.14.18.1 (1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one
-
 Agaricus bisporus
1.14.18.1 (1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
-
 Agaricus bisporus
1.14.18.1 (2E,6E)-2,6-bis[(4-chlorophenyl)methylidene]cyclohexanone
-
 Agaricus bisporus
1.14.18.1 (2E,6E)-2,6-bis[(4-hydroxyphenyl)methylidene]cyclohexanone
-
 Agaricus bisporus
1.14.18.1 1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one
-
 Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one + O2
-
 Agaricus bisporus ?
-
 ?
1.14.18.1 L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.06655
-
-
 Agaricus bisporus kojic acid
1.14.18.1 0.07905
-
-
 Agaricus bisporus 1,5-bis(4-hydroxyphenyl)-1,4-pentadiene-3-one
1.14.18.1 0.25
-
 IC50 above 0.25 mM Agaricus bisporus (1E,4E)-1,5-bis(4-fluorophenyl)penta-1,4-dien-3-one
1.14.18.1 0.25
-
 IC50 above 0.25 mM Agaricus bisporus (1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
1.14.18.1 0.25
-
 IC50 above 0.25 mM Agaricus bisporus (1E,4E)-1,5-bis(2-fluoro-4-methoxyphenyl)penta-1,4-dien-3-one
1.14.18.1 0.25
-
 IC50 above 0.25 mM Agaricus bisporus (2E,6E)-2,6-bis[(4-hydroxyphenyl)methylidene]cyclohexanone
1.14.18.1 0.25
-
 IC50 above 0.25 mM Agaricus bisporus (2E,6E)-2,6-bis[(4-chlorophenyl)methylidene]cyclohexanone