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Literature summary extracted from

  • Schmidt, A.; Bilgasem, S.; Lorkowski, S.; Vischer, P.; Voelker, W.; Breithardt, G.; Siegel, G.; Buddecke, E.
    Exogenous nitric oxide regulates activity and synthesis of vascular endothelial nitric oxide synthase (2008), Eur. J. Clin. Invest., 38, 476-485.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.13.39 additional information short-term (20-30 min) treatment of endothelial cells with the synthetic NO donor (Z)-1-[2-(2-aminoethyl)-N-(2-aminoethyl)amino](diazen-1-ium-1,2-diolate) increases the Ser1177 phosphorylation of the constitutively expressed endothelial NOS and the production of endogenous NO generated by eNOS from L-arginine, the phosphorylation of eNOS is Akt-dependent and completely reverted by the phosphatidylinositol-3 kinase inhibitor LY-294002 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.39 N-nitro-L-arginine methyl ester competitive NOS inhibitor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.39 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.39 endothelial cell
-
Homo sapiens
-
1.14.13.39 HUVEC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.39 2 L-arginine + 3 NADPH + 3 H+ + 4 O2
-
Homo sapiens 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
-
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Synonyms

EC Number Synonyms Comment Organism
1.14.13.39 endothelial nitric oxide synthase
-
Homo sapiens
1.14.13.39 endothelial NO synthase
-
Homo sapiens
1.14.13.39 eNOS
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.39 5,6,7,8-tetrahydro-L-biopterin
-
Homo sapiens
1.14.13.39 Calmodulin
-
Homo sapiens
1.14.13.39 NADPH
-
Homo sapiens