EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | additional information | short-term (20-30 min) treatment of endothelial cells with the synthetic NO donor (Z)-1-[2-(2-aminoethyl)-N-(2-aminoethyl)amino](diazen-1-ium-1,2-diolate) increases the Ser1177 phosphorylation of the constitutively expressed endothelial NOS and the production of endogenous NO generated by eNOS from L-arginine, the phosphorylation of eNOS is Akt-dependent and completely reverted by the phosphatidylinositol-3 kinase inhibitor LY-294002 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | N-nitro-L-arginine methyl ester | competitive NOS inhibitor | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.13.39 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.13.39 | endothelial cell | - |
Homo sapiens | - |
1.14.13.39 | HUVEC cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.13.39 | 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | - |
Homo sapiens | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.13.39 | endothelial nitric oxide synthase | - |
Homo sapiens |
1.14.13.39 | endothelial NO synthase | - |
Homo sapiens |
1.14.13.39 | eNOS | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.13.39 | 5,6,7,8-tetrahydro-L-biopterin | - |
Homo sapiens | |
1.14.13.39 | Calmodulin | - |
Homo sapiens | |
1.14.13.39 | NADPH | - |
Homo sapiens |