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Literature summary extracted from

  • Sohling, B.; Gottschalk, G.
    Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri (1993), Eur. J. Biochem., 212, 121-127.
    View publication on PubMed

General Stability

EC Number General Stability Organism
1.2.1.76 enzyme is air-sensitive. Exposure to air at room temperature or 4°C results in a complete inactivation within 6 h or 24 h, respectively Clostridium kluyveri

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.76 2.7
-
Succinate-semialdehyde pH 8.5, 30°C Clostridium kluyveri
1.2.1.76 2.9
-
coenzyme A pH 8.5, 30°C Clostridium kluyveri
1.2.1.76 3.2
-
succinyl-CoA pH 7.0, 30°C Clostridium kluyveri
1.2.1.76 4
-
NADP+ pH 8.5, 30°C Clostridium kluyveri
1.2.1.76 4.3
-
NADPH pH 7.0, 30°C Clostridium kluyveri

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.76 55000
-
2 * 55000, SDS-PAGE Clostridium kluyveri
1.2.1.76 115000
-
sucrose gradient centrifugation Clostridium kluyveri

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.76 Clostridium kluyveri
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.76
-
Clostridium kluyveri

Reaction

EC Number Reaction Comment Organism Reaction ID
1.2.1.76 succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+ ping-pong mechanism Clostridium kluyveri

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.76 41.4
-
pH 7.0, 30°C Clostridium kluyveri

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.76 caproaldehyde + coenzyme A + NADP+ at 8.6% of the rate with succinate-semialdehyde Clostridium kluyveri n-hexanoyl-CoA + NADPH + H+
-
r
1.2.1.76 glutaryl-CoA + NADPH + H+ at 6.7% of the rate with succinyl-coA Clostridium kluyveri ? + coenzyme A + NADP+
-
r
1.2.1.76 glycolaldehyde + coenzyme A + NADP+ at 9.1% of the rate with succinate-semialdehyde Clostridium kluyveri ? + NADPH + H+
-
r
1.2.1.76 n-butyraldehyde + coenzyme A + NADP+ at 1% of the rate with succinate-semialdehyde Clostridium kluyveri n-butyryl-CoA + NADPH + H+
-
r
1.2.1.76 n-hexanoyl-CoA + NADPH + H+ at 8.1% of the rate with succinyl-coA Clostridium kluyveri caproaldehyde + coenzyme A + NADP+
-
r
1.2.1.76 palmitoyl-CoA + NADPH + H+ at 15.1% of the rate with succinyl-coA Clostridium kluyveri ? + coenzyme A + NADP+
-
r
1.2.1.76 succinate-semialdehyde + coenzyme A + NADP+
-
Clostridium kluyveri succinyl-CoA + NADPH + H+
-
r
1.2.1.76 succinyl-CoA + NADPH + H+
-
Clostridium kluyveri succinate-semialdehyde + coenzyme A + NADP+
-
r
1.2.1.76 valeraldehyde + coenzyme A + NADP+ at 6.0% of the rate with succinate-semialdehyde Clostridium kluyveri n-valeryl-CoA + NADPH + H+
-
r

Subunits

EC Number Subunits Comment Organism
1.2.1.76 dimer 2 * 55000, SDS-PAGE Clostridium kluyveri

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.76 7
-
reduction of succinyl-CoA Clostridium kluyveri
1.2.1.76 8.5
-
oxidation of succinate-semialdehyde Clostridium kluyveri