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Literature summary extracted from

  • De Chaudhuri, S.; Ghosh, P.; Sarma, N.; Majumdar, P.; Sau, T.J.; Basu, S.; Roychoudhury, S.; Ray, K.; Giri, A.K.
    Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes (2008), Environ. Health Perspect., 116, 501-505.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.137 genotyping Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.137 M287T naturally occuring mutant Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.137 additional information Homo sapiens As3MT methylates inorganic arsenic and its metabolites ?
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?
2.1.1.137 S-adenosyl-L-methionine + arsenite Homo sapiens As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview S-adenosyl-L-homocysteine + methylarsonate
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?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Homo sapiens Q9HBK9
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 additional information As3MT methylates inorganic arsenic and its metabolites Homo sapiens ?
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite As3MT enzyme is indispensable for conversion of the arsenic metabolites to their corresponding methylated products, metabolism of arsenic proceeds through sequential reduction and oxidative methylation involving several enzymes including the arsenic (+3) methyltransferase, overview Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.137 arsenic (+3) methyltransferase
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Homo sapiens
2.1.1.137 AS3MT
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Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.137 S-adenosyl-L-methionine
-
Homo sapiens