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Literature summary extracted from

  • Boelen, A.; Kwakkel, J.; Wieland, C.W.; St Germain, D.L.; Fliers, E.; Hernandez, A.
    Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae (2009), Endocrinology, 150, 1984-1990.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.21.99.3 additional information by activation of type 3 deiodinase during illness reduction of thyroid hormone levels Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.3 triiodothyronine
-
Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.3 Mus musculus
-
wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
-
1.21.99.4 Mus musculus Q61153 wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
-
1.21.99.4 Mus musculus Q9Z148 wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.3 liver
-
Mus musculus
-
1.21.99.4 hypothalamus
-
Mus musculus
-
1.21.99.4 liver
-
Mus musculus
-
1.21.99.4 pituicyte
-
Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.99.4 0.0000000005
-
pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae Mus musculus
1.21.99.4 0.00000000075
-
pituitary type 2 deiodinase activity, wild-type mice after infection with Streptococcus pneumoniae Mus musculus
1.21.99.4 0.0000000014
-
value about, pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice Mus musculus
1.21.99.4 0.0000000015
-
value about, pituitary type 2 deiodinase activity, wild-type mice Mus musculus
1.21.99.4 0.00000075
-
type 3 deiodinase knockout mice Mus musculus
1.21.99.4 0.000001
-
type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae Mus musculus
1.21.99.4 0.00000125
-
wild-type mice after infection with Streptococcus pneumoniae Mus musculus
1.21.99.4 0.000002
-
wild-type mice Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.3 3,3',5'-triido-L-thyronine + iodide + A + H+ assay at pH 7.2 Mus musculus L-thyroxine + AH2
-
?
1.21.99.4 3,5,3'-triiodo-L-thyronine + iodide + A + H+ assay at pH 7.2 Mus musculus L-thyroxine + AH2
-
?
1.21.99.4 L-thyroxine + AH2 assay at pH 7.2 Mus musculus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.21.99.3 type 3 deiodinase
-
Mus musculus
1.21.99.4 type 1 deiodinase
-
Mus musculus
1.21.99.4 type 2 deiodinase
-
Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.99.3 7.2
-
assay at Mus musculus
1.21.99.4 7.2
-
assay at Mus musculus

Expression

EC Number Organism Comment Expression
1.21.99.4 Mus musculus decrease of liver type 1 deiodinase levels after infection only in wild-type mice, low expression levels in type 3 deiodinase knockout mice down
1.21.99.4 Mus musculus decrease of pituitary type 2 deiodinase levels after infection down

General Information

EC Number General Information Comment Organism
1.21.99.3 physiological function role in innate immune response, reduction of thyroid hormone levels during illness, protective role in defense against acute bacterial infection, probably by reinforcement of microbial killing capacity of neutrophils Mus musculus