EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.3 | additional information | by activation of type 3 deiodinase during illness reduction of thyroid hormone levels | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.21.99.3 | triiodothyronine | - |
Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.21.99.3 | Mus musculus | - |
wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae | - |
1.21.99.4 | Mus musculus | Q61153 | wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae | - |
1.21.99.4 | Mus musculus | Q9Z148 | wild-type and type 3 deiodinase knockout mice, infected with Streptococcus pneumoniae | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.21.99.3 | liver | - |
Mus musculus | - |
1.21.99.4 | hypothalamus | - |
Mus musculus | - |
1.21.99.4 | liver | - |
Mus musculus | - |
1.21.99.4 | pituicyte | - |
Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.21.99.4 | 0.0000000005 | - |
pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae | Mus musculus |
1.21.99.4 | 0.00000000075 | - |
pituitary type 2 deiodinase activity, wild-type mice after infection with Streptococcus pneumoniae | Mus musculus |
1.21.99.4 | 0.0000000014 | - |
value about, pituitary type 2 deiodinase activity, type 3 deiodinase knockout mice | Mus musculus |
1.21.99.4 | 0.0000000015 | - |
value about, pituitary type 2 deiodinase activity, wild-type mice | Mus musculus |
1.21.99.4 | 0.00000075 | - |
type 3 deiodinase knockout mice | Mus musculus |
1.21.99.4 | 0.000001 | - |
type 3 deiodinase knockout mice after infection with Streptococcus pneumoniae | Mus musculus |
1.21.99.4 | 0.00000125 | - |
wild-type mice after infection with Streptococcus pneumoniae | Mus musculus |
1.21.99.4 | 0.000002 | - |
wild-type mice | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.21.99.3 | 3,3',5'-triido-L-thyronine + iodide + A + H+ | assay at pH 7.2 | Mus musculus | L-thyroxine + AH2 | - |
? | |
1.21.99.4 | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | assay at pH 7.2 | Mus musculus | L-thyroxine + AH2 | - |
? | |
1.21.99.4 | L-thyroxine + AH2 | assay at pH 7.2 | Mus musculus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.21.99.3 | type 3 deiodinase | - |
Mus musculus |
1.21.99.4 | type 1 deiodinase | - |
Mus musculus |
1.21.99.4 | type 2 deiodinase | - |
Mus musculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.21.99.3 | 7.2 | - |
assay at | Mus musculus |
1.21.99.4 | 7.2 | - |
assay at | Mus musculus |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.21.99.4 | Mus musculus | decrease of liver type 1 deiodinase levels after infection only in wild-type mice, low expression levels in type 3 deiodinase knockout mice | down |
1.21.99.4 | Mus musculus | decrease of pituitary type 2 deiodinase levels after infection | down |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.21.99.3 | physiological function | role in innate immune response, reduction of thyroid hormone levels during illness, protective role in defense against acute bacterial infection, probably by reinforcement of microbial killing capacity of neutrophils | Mus musculus |