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Literature summary extracted from

  • Volonte, D.; Galbiati, F.
    Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence (2009), EMBO Rep., 10, 1334-1340.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 calveolin overexpression of caveolin 1 inhibits TrxR activity by about 50% whereas a lack of caveolin 1 activates TrxR, both in vitro and in vivo Homo sapiens
1.8.1.9 calveolin overexpression of caveolin 1 inhibits TrxR activity by about 50% whereas a lack of caveolin 1 activates TrxR, both in vitro and in vivo Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 membrane calveolar membrane Mus musculus 16020
-
1.8.1.9 membrane calveolar membrane Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens Q16881
-
-
1.8.1.9 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 MCF-7 cell
-
 Homo sapiens
-
1.8.1.9 NIH-3T3 cell
-
 Mus musculus
-
1.8.1.9 WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + insulin
-
 Mus musculus thioredoxin + insulin disulfide
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Mus musculus thioredoxin + NADP+
-
 ?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase 1
-
 Mus musculus
1.8.1.9 thioredoxin reductase 1
-
 Homo sapiens
1.8.1.9 TrxR1
-
 Mus musculus
1.8.1.9 TrxR1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Mus musculus
1.8.1.9 NADPH
-
 Homo sapiens