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Literature summary extracted from

  • Boonyapiwat, B.; Forbes, B.; Mitchell, S.; Steventon, G.B.
    Phenylalanine 4-monooxygenase and the S-oxidation of S-carboxymethyl-L-cysteine by human cytosolic fractions (2008), Drug Metabol. Drug Interact., 23, 261-282.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.16.1 2,2'-dipyridyl 99.0% inhibition at 1.0 mM using L-phenylalanine as substrate, 99.0% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate Homo sapiens
1.14.16.1 3-iodotyrosine 3.0% inhibition at 1.0 mM using L-phenylalanine as substrate, 5.2% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate Homo sapiens
1.14.16.1 4-Chlorophenylalanine specific PAH inhibitor, 97.2% inhibition at 1.0 mM using L-phenylalanine as substrate, 99.2% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate Homo sapiens
1.14.16.1 6-Fluorotryptophan 2.5% inhibition at 1.0 mM using L-phenylalanine as substrate, 4.5% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate Homo sapiens
1.14.16.1 L-phenylalanine competitive inhibition of the S-oxidation of S-carboxymethyl-L-cysteine, 92.8% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate Homo sapiens
1.14.16.1 additional information not inhibited by the nitric oxide synthase inhibitors N(G)-monomethyl-D-arginine, 7-nitroindazole, L-thiocitrulline, N(G)-monomethyl-L-arginine, (S)-methy-L-thiocitrulline, and L-N5-(1-iminoethyl)ornithine; PH8, the large aromatic amino acid hydroxylase monoclonal antibody, inhibits the production of both L-tyrosine and S-carboxymethyl-L-cysteine S-oxide to 99.0% and 99.3% at 0.2 mg/ml concentration Homo sapiens
1.14.16.1 S-carboxymethyl-L-cysteine competitive inhibitor of the aromatic C-oxidation of L-phenylalanine, 25.2% inhibition at 5.0 mM using L-phenylalanine as substrate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.16.1 0.0231
-
 5,6,7,8-tetrahydrobiopterin using L-phenylalanine as cosubstrate, in pooled hepatic cytosolic enzyme fraction, at 37°C Homo sapiens
1.14.16.1 0.02333
-
 5,6,7,8-tetrahydrobiopterin using L-phenylalanine as cosubstrate, in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C Homo sapiens
1.14.16.1 0.07312
-
 5,6,7,8-tetrahydrobiopterin using S-carboxymethyl-L-cysteine as cosubstrate, in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C Homo sapiens
1.14.16.1 0.07812
-
 5,6,7,8-tetrahydrobiopterin using S-carboxymethyl-L-cysteine as cosubstrate, in pooled hepatic cytosolic enzyme fraction, at 37°C Homo sapiens
1.14.16.1 0.16
-
 L-phenylalanine in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C Homo sapiens
1.14.16.1 3.05
-
 L-phenylalanine in pooled hepatic cytosolic enzyme fraction, at 37°C Homo sapiens
1.14.16.1 16.22
-
 S-carboxymethyl-L-cysteine
-
 Homo sapiens
1.14.16.1 16.53
-
 S-carboxymethyl-L-cysteine in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.16.1 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.1 L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.1 S-carboxymethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2
-
 Homo sapiens S-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.1 PAH
-
 Homo sapiens
1.14.16.1 phenylalanine hydroxylase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.16.1 5,6,7,8-tetrahydro-L-biopterin
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.16.1 17.23
-
 S-carboxymethyl-L-cysteine in pooled hepatic cytosolic enzyme fraction, at 37°C Homo sapiens