Literature summary extracted from

Strate, I.; Min, T.H.; Iliev, D.; Pera, E.M.
Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system (2009), Development, 136, 461-472.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.1.1.105	expressed in HEK-293T cells	Xenopus laevis

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.105	additional information	treatment with 0.005 mM retinoic acid induces a severe reduction of RDH10 expression, a combination of retinal dehydrogenase 2 mRNA and treatment with 0.005 mM retinal causes a robust downregulation of RDH10 transcription	Xenopus laevis

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.105	additional information	Xenopus laevis	RDH10 is required for proper retinoic acid signalling in the early embryo, RDH10 cooperates with retinal dehydrogenase 2 during axis development and central nervous system patterning	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.105	Xenopus laevis	C3TWL9	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.105	embryo	dorsal blastopore lip	Xenopus laevis	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.105	additional information	RDH10 is required for proper retinoic acid signalling in the early embryo, RDH10 cooperates with retinal dehydrogenase 2 during axis development and central nervous system patterning	Xenopus laevis	?	-	?
1.1.1.105	retinal + NADH + H+	-	Xenopus laevis	retinol + NAD+	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.105	RDH10	-	Xenopus laevis
1.1.1.105	retinol dehydrogenase 10	-	Xenopus laevis

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.105	NADH	-	Xenopus laevis

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Release 2023.1 (January 2023)