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Literature summary extracted from

  • Lu, Q.; Longo, F.M.; Zhou, H.; Massa, S.M.; Chen, Y.H.
    Signaling through Rho GTPase pathway as viable drug target (2009), Curr. Med. Chem., 16, 1355-1365.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.2 additional information Rho kinase is an important downstream effector of RhoA GTPases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.2 atorvastatin marketed as Lipitor, i.e. [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, inhibits RhoA activity by reducing Rho geranylgeranylation Homo sapiens
3.6.5.2 CCG-1423
-
 Homo sapiens
3.6.5.2 CCG-977
-
 Homo sapiens
3.6.5.2 cerivastatin marketed as Baycol/Lipobay, i.e. (E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyridin-3-yl]-3,5-dihydroxy-hept-6-enoic acid, RhoA inhibitor Homo sapiens
3.6.5.2 lovastatin marketed as Mevacor, i.e. 8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-[hexahydronaphthalen-1-yl]2-methylbutanoate Homo sapiens
3.6.5.2 NSC23766 not very potent inhibitor of Rac1 and Cdc42 Homo sapiens
3.6.5.2 simvastatin marketed as Zocor, i.e. [(1S,3R,7R,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-oxan-2-yl]ethyl]3.7-dimethyl]-1,2,3,7,8,8a-[hexahydronaphthalen-1-yl]2,2-dimethylbutanoate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.5.2 membrane
-
 Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.2 erythroleukemia cell
-
 Homo sapiens
-
3.6.5.2 HT-29 cell
-
 Homo sapiens
-
3.6.5.2 MDA-MB-231 cell
-
 Homo sapiens
-
3.6.5.2 PC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.2 GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.2 Cdc42
-
 Homo sapiens
3.6.5.2 Rac1
-
 Homo sapiens
3.6.5.2 Rho GTPase
-
 Homo sapiens
3.6.5.2 RhoA
-
 Homo sapiens