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Literature summary extracted from

  • Federico, L.; Pamuklar, Z.; Smyth, S.S.; Morris, A.J.
    Therapeutic potential of autotaxin/lysophospholipase d inhibitors (2008), Curr. Drug Targets, 9, 698-708.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.39 1-acyl glycerol 3-phosphate also fatty alcohol phosphates (structurally 1-acyl glycerol 3-phosphate analogs) Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.39 additional information
-
 additional information capable of hydrolyzing sphingosylphosphorylcholine with a significantly higher km-value, also able to hydrolyze nucleotide triphosphates di-adenosine polyphosphates and artificial phosphodiester substrates such as p-nitrophenyl thymidine phosphate with Km-values close to 1 and optimal activity observed at alkaline pH Mus musculus
3.1.4.39 0.1
-
 1-alkyl-sn-glycero-3-phosphoethanolamine achieved under optimal assay conditions, almost same results in blood plasma Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 1-alkyl-sn-glycero-3-phosphoethanolamine + H2O Mus musculus
-
 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.39 glycoprotein
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Mus musculus 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
 Mus musculus
3.1.4.39 autotaxin
-
 Mus musculus
3.1.4.39 lysoPLD plasma lysoPLD is predominant form (863 amino acids), 2 further forms known - first contains 52 residue and second contains 24 residue insertions close to phosphodieseterase domain Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.4.39 0.0001
-
 1-acyl glycerol 3-phosphate CPF4 FRET assay (change of fluorescence intensity), inihibition involves both a reduction in vmax and an increase in km, binding affinity is 1000fold stronger than to 1-alkyl-sn-glycero-3-phosphoethanolamine and analogue substrates Mus musculus