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Literature summary extracted from

  • Benes, P.; Vetvicka, V.; Fusek, M.
    Cathepsin D - many functions of one aspartic protease (2008), Crit. Rev. Oncol. Hematol., 68, 12-28.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.5 endosome
-
 Homo sapiens 5768
-
3.4.23.5 lysosome
-
 Homo sapiens 5764
-
3.4.23.5 phagosome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.5 additional information
-
 procathepsin D: 52000 Da, single chain intermediate active enzyme form: 48000 Da, mature protease: 34000 Da (heavy chain) and 14000 Da (light chain) Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.5 actin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 alpha-synuclein + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 alpha1-Antichymotrypsin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 amyloid beta A4 protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 androgen receptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 apolipoprotein B + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 apolipoprotein E + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 BID + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 cathepsin B + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 cathepsin L + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 collagens + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 connectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 cystatin C + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 dermcidin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 endostatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Fibrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Fibrinogen + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 fibroblast growth factor + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Glucagon + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Hemoglobin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 insulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 insulin-like growth factor binding protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 interleukin-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 kallistatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 kininogen + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 macrophage inflammatory protein-1 alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 macrophage inflammatory protein-1 beta + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 mutant huntingtin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 myelin basic protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 myosin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 neurofilaments + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 osteocalcin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Parathyroid hormone + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 plasminogen + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 prolactin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 prosaposin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 proteoglycans + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 secondary lymphoid-tissue chemokine + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 Tau + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 thioredoxin-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 thyroglobulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 transglutaminase 1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 tropomyosin + H2O
-
 Homo sapiens ?
-
 ?
3.4.23.5 tubulin + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.5 cathepsin D
-
 Homo sapiens